BRAF p.G469A Reference Standard
CBP10235
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| Introduction | |
| Format | Genomic DNA |
| Description | BRAF G469A is a hotspot mutation within the protein kinase domain of the Braf protein (UniProt.org). G469A results in increased Braf kinase activity and downstream activation of Erk, and is transforming in cell culture (PMID: 19010912, PMID: 12068308, PMID: 29533785). |
| Technical Data | |
| DNA Change | c.1406G>C |
| AA Change | p.G469A |
| Mutation type | Substitution - Missense |
| Zygosity | Heterozygous |
| Allelic Frequency | 80% |
| Transcript | ENST00000288602 |
| Cosmic ID | COSM460 |
| Chr position(GRCh37) | chr7:140481402 |
| Buffer | Tris-EDTA |
| Product Information | |
| Intended Use | Research Use Only |
| Unit Size | 1ug |
| Concentration | Download for COA |
| Purofication | Download for COA |
| DNA electrophoresis | Download for COA |
| Sanger sequencing |  |
| Storage | 2-8℃ |
| Expiry | 36 months from the date of manufacture |
