HIF-Luc/786-o
CBP74213
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| I. Background | |
| Hypoxia-inducible factor (HIF) is the major transcriptional regulator mediating the cellular physiological response to reduced levels of oxygen (hypoxia). Upregulated as a consequence, both of intra-tumour hypoxia and through activation of oncogenic pathways, HIF has an important role in the pathogenesis of many cancers. | |
| II. Introduction | |
| Host Cell: | 786-o |
| Expressed gene: | HIF-Luc |
| Stability: | 32 passages (in-house test, that not means the cell line will be instable beyond the passages we tested.) |
| Freeze Medium: | 90% FBS+10% DMSO |
| Culture Medium: | RPMI-1640+10%FBS+150ug/ml hygromycin |
| Storage: | Liquid nitrogen |
| III. Description of Host Cell Line | |
| Organism: | Homo sapiens, human |
| Tissue: | kidney |
| Disease: | carcinoma |
| Morphology: | epithelial |
| Growth Properties: | adherent |
| IV. Representative Data | |
 Figure 1. Induction of HIF Activity by PT2385 in HIF-Luc 786-o(C2). |
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